MapQuest Driving Directions Des Moines, IA to Saint Louis, MO

Des Moines, IA

Saint Louis, MO

Route 1

Go east on I-235 E.
349.557 miles
5hr 47min
  1. Start out going north on 2nd Ave toward Watson Powell Jr Way.

    Then 0.45 miles
  2. Merge onto I-235 E.

    1. If you reach Laurel St you've gone about 0.1 miles too far

    Then 1.39 miles
  3. Merge onto IA-163 E via EXIT 10A toward State Fairgrounds.

    Then 60.93 miles
  4. IA-163 E becomes US-63 S.

    Then 26.27 miles
  5. Turn slight left to take the US-34 E ramp toward IA-163 E/Fairfield.

    Then 0.59 miles
  6. Stay straight to go onto US-34 E/Highway 34. Continue to follow US-34 E.

    Then 49.99 miles
  7. Stay straight to go onto US-218 S/IA-27/Highway 218. Continue to follow IA-27 (Crossing into Missouri).

    Then 34.97 miles
  8. IA-27 becomes MO-27.

    Then 7.01 miles
  9. Stay straight to go onto US-61 S.

    Then 44.41 miles
  10. Turn slight left onto US-61 S/Highway 61 N. Continue to follow US-61 S.

    1. US-61 S is just past Highway F

    Then 111.44 miles
  11. Stay straight to go onto I-64 E/US-40 E.

    Then 11.44 miles
  12. Take the 14th St exit, EXIT 39A.

    Then 0.20 miles
  13. Turn left onto S 14th St.

    Then 0.48 miles
  14. Welcome to SAINT LOUIS, MO.

    1. Your destination is just past Pine St

    2. If you reach Locust St you've gone a little too far

    Then 0.00 miles