MapQuest Driving Directions Iowa City, IA to Saint Louis, MO

Iowa City, IA

Saint Louis, MO

Route 1

Go west on E Burlington St/IA-1.
260.912 miles
4hr 15min
  1. Start out going south on S Gilbert St toward Eastlawn.

    Then 0.24 miles
  2. Turn right onto E Burlington St/IA-1/County Hwy-W66. Continue to follow E Burlington St/IA-1.

    1. E Burlington St is just past E College St

    2. Papa John's Pizza is on the corner

    3. If you reach E Court St you've gone a little too far

    Then 0.61 miles
  3. Turn left onto S Riverside Dr/US-6 E/IA-1. Continue to follow S Riverside Dr.

    1. S Riverside Dr is 0.1 miles past Front St

    2. If you are on Grand Ave and reach Byington Rd you've gone a little too far

    Then 1.41 miles
  4. Stay straight to go onto Old Highway 218 S.

    Then 1.70 miles
  5. Merge onto IA-27 S toward Mt Pleasant (Crossing into Missouri).

    Then 81.98 miles
  6. IA-27 S becomes MO-27.

    Then 7.01 miles
  7. Stay straight to go onto US-61 S.

    Then 44.41 miles
  8. Turn slight left onto US-61 S/Highway 61 N. Continue to follow US-61 S.

    1. US-61 S is just past Highway F

    Then 111.44 miles
  9. Stay straight to go onto I-64 E/US-40 E.

    Then 11.44 miles
  10. Take the 14th St exit, EXIT 39A.

    Then 0.20 miles
  11. Turn left onto S 14th St.

    Then 0.48 miles
  12. Welcome to SAINT LOUIS, MO.

    1. Your destination is just past Pine St

    2. If you reach Locust St you've gone a little too far

    Then 0.00 miles