MapQuest Driving Directions Sioux City, IA to Saint Louis, MO

Sioux City, IA

Saint Louis, MO

Route 1

529.069 miles
8hr 5min
  1. Start out going west on 6th St/US-20 Bus W toward Pearl St.

    Then 0.22 miles
  2. Take the 3rd left onto Wesley Pkwy/US-20 Bus W.

    1. Wesley Pkwy is just past Water St

    2. If you are on W 4th St and reach Perry St you've gone a little too far

    Then 0.39 miles
  3. Merge onto I-29 S via the ramp on the left.

    Then 99.63 miles
  4. Keep right to take I-29 S via EXIT 4 toward Kansas City (Crossing into Missouri).

    Then 158.39 miles
  5. Merge onto I-435 E via EXIT 14 toward St Louis.

    Then 28.39 miles
  6. Merge onto I-70 E via EXIT 63B on the left toward St Louis.

    Then 201.92 miles
  7. Merge onto I-64 E/US-40 E via EXIT 210A toward Chesterfield.

    Then 39.46 miles
  8. Take the 14th St exit, EXIT 39A.

    Then 0.20 miles
  9. Turn left onto S 14th St.

    Then 0.48 miles
  10. Welcome to SAINT LOUIS, MO.

    1. Your destination is just past Pine St

    2. If you reach Locust St you've gone a little too far

    Then 0.00 miles