MapQuest Driving Directions Waterloo, IA to Saint Louis, MO

Waterloo, IA

Saint Louis, MO

Route 1

338.593 miles
5hr 24min
  1. Start out going southeast on Washington St.

    Then 2.80 miles
  2. Merge onto I-380 S/US-20 E/IA-27 S via EXIT 71 toward Cedar Rapids/Dubuque.

    Then 6.55 miles
  3. Merge onto IA-27 S toward Cedar Rapids (Crossing into Missouri).

    Then 154.28 miles
  4. IA-27 S becomes MO-27.

    Then 7.01 miles
  5. Stay straight to go onto US-61 S.

    Then 44.41 miles
  6. Turn slight left onto US-61 S/Highway 61 N. Continue to follow US-61 S.

    1. US-61 S is just past Highway F

    Then 111.44 miles
  7. Stay straight to go onto I-64 E/US-40 E.

    Then 11.44 miles
  8. Take the 14th St exit, EXIT 39A.

    Then 0.20 miles
  9. Turn left onto S 14th St.

    Then 0.48 miles
  10. Welcome to SAINT LOUIS, MO.

    1. Your destination is just past Pine St

    2. If you reach Locust St you've gone a little too far

    Then 0.00 miles