MapQuest Driving Directions Indianapolis, IN to Charleston, SC

Indianapolis, IN

Charleston, SC

Route 1

Go south on I-65 S/I-70 W.
727.438 miles
11hr 10min
  1. Start out going east on E Market St toward N Talbott St.

    Then 0.67 miles
  2. Turn right onto N Davidson St.

    1. N Davidson St is just past Spring St

    2. If you reach N Pine St you've gone a little too far

    Then 0.34 miles
  3. Merge onto I-65 S/I-70 W via the ramp on the left toward Louisville/St Loius.

    Then 0.58 miles
  4. Keep left to take I-65 S toward Louisville (Crossing into Kentucky).

    Then 110.83 miles
  5. Merge onto I-71 N via EXIT 137 toward I-64 E/Cincinnati/Lexington.

    Then 0.77 miles
  6. Merge onto I-64 E toward Lexington.

    Then 75.26 miles
  7. Take I-75 S toward Richmond/Knoxville (Crossing into Tennessee).

    Then 164.70 miles
  8. Stay straight to go onto I-275 S.

    Then 0.37 miles
  9. Merge onto I-640 E/US-25W S/TN-9 E via EXIT 3 toward Asheville.

    Then 6.98 miles
  10. Merge onto I-40 E via the exit on the left toward Asheville.

    Then 28.51 miles
  11. Keep right to take I-40 E toward Asheville (Crossing into North Carolina).

    Then 76.21 miles
  12. Merge onto I-26 E via EXIT 46A toward Hendersonville/Spartanburg (Crossing into South Carolina).

    Then 260.27 miles
  13. Take the Meeting St exit, EXIT 221B, on the left toward Visitor Ctr.

    Then 0.39 miles
  14. Turn right onto US-52 E/Meeting St. Continue to follow Meeting St.

    1. If you are on US-52 W and reach Lee St you've gone a little too far

    Then 1.57 miles
  15. Welcome to CHARLESTON, SC.

    1. Your destination is just past Court House Sq

    2. If you reach Saint Michaels Aly you've gone a little too far

    Then 0.00 miles