MapQuest Driving Directions Lexington, KY to Des Moines, IA

Lexington, KY

Des Moines, IA

Route 1

663.82 miles
10hr 15min
  1. Start out going northwest on W Main St/US-60 W/US-25 N/US-421 N toward Wrehn Ct. Continue to follow W Main St/US-25 N/US-421 N.

    Then 0.72 miles
  2. Turn right onto Newtown Pike/US-25 N. Continue to follow Newtown Pike.

    1. Newtown Pike is 0.1 miles past Old Georgetown St

    2. If you reach Buchanan St you've gone about 0.2 miles too far

    Then 3.39 miles
  3. Merge onto I-75 N/I-64 W toward Louisville/Cincinnati.

    Then 2.55 miles
  4. Keep left to take I-64 W via EXIT 118 toward Frankfort/Louisville.

    Then 68.83 miles
  5. Merge onto I-71 S via EXIT 5A on the left toward I-65/Nashville/Indianapolis.

    Then 0.49 miles
  6. Merge onto I-65 N via the exit on the left toward Indianapolis (Crossing into Indiana).

    Then 106.48 miles
  7. Merge onto I-74 W/I-465 W via EXIT 106.

    Then 15.72 miles
  8. Merge onto I-74 W via EXIT 16B toward Peoria (Crossing into Illinois).

    Then 166.18 miles
  9. Merge onto I-74 W via EXIT 163 toward Peoria.

    Then 114.01 miles
  10. Merge onto I-80 W via the exit on the left toward Davenport (Crossing into Iowa).

    Then 178.94 miles
  11. Merge onto I-235 W via EXIT 137A on the left toward Des Moines.

    Then 5.68 miles
  12. Take EXIT 8A toward Downtown Des Moines/lowa State Center.

    Then 0.12 miles
  13. Merge onto 3rd St toward Civic Center/Science Center/Principal Park.

    Then 0.67 miles
  14. Turn left onto Grand Ave.

    1. Grand Ave is just past Watson Powell Jr Way

    2. If you reach Locust St you've gone a little too far

    Then 0.06 miles
  15. Welcome to DES MOINES, IA.

    1. If you reach Robert D Ray Dr you've gone about 0.2 miles too far

    Then 0.00 miles