MapQuest Driving Directions Louisville, KY to Columbia, SC

Louisville, KY

Columbia, SC

Route 1

505.784 miles
7hr 47min
  1. Start out going west on W Main St/US-60 W/US-31E N toward S 2nd St/US-31 S/US-31 N.

    Then 0.10 miles
  2. Take the 1st right onto N 2nd St/US-31 N.

    1. Courtyard By Marriott Louisville Downtown is on the corner

    2. If you reach S 3rd St you've gone a little too far

    Then 0.01 miles
  3. Keep right at the fork to go on N 2nd St.

    Then 0.63 miles
  4. Stay straight to go onto I-64 E.

    Then 75.99 miles
  5. Take I-75 S toward Richmond/Knoxville (Crossing into Tennessee).

    Then 164.70 miles
  6. Stay straight to go onto I-275 S.

    Then 0.37 miles
  7. Merge onto I-640 E/US-25W S/TN-9 E via EXIT 3 toward Asheville.

    Then 6.98 miles
  8. Merge onto I-40 E via the exit on the left toward Asheville.

    Then 28.51 miles
  9. Keep right to take I-40 E toward Asheville (Crossing into North Carolina).

    Then 76.21 miles
  10. Merge onto I-26 E via EXIT 46A toward Hendersonville/Spartanburg (Crossing into South Carolina).

    Then 147.75 miles
  11. Keep left to take US-76 E via EXIT 108B toward Downtown Columbia.

    Then 4.25 miles
  12. Turn right onto Main St.

    1. Main St is just past Assembly St

    2. If you reach Sumter St you've gone a little too far

    Then 0.30 miles
  13. Welcome to COLUMBIA, SC.

    1. Your destination is just past Richland St

    2. If you reach Blanding St you've gone a little too far

    Then 0.00 miles