MapQuest Driving Directions Louisville, KY to Knoxville, TN

Louisville, KY

Knoxville, TN

Route 1

245.864 miles
3hr 45min
  1. Start out going west on W Main St/US-60 W/US-31E N toward S 2nd St/US-31 S/US-31 N.

    Then 0.10 miles
  2. Take the 1st right onto N 2nd St/US-31 N.

    1. Courtyard By Marriott Louisville Downtown is on the corner

    2. If you reach S 3rd St you've gone a little too far

    Then 0.01 miles
  3. Keep right at the fork to go on N 2nd St.

    Then 0.63 miles
  4. Stay straight to go onto I-64 E.

    Then 75.99 miles
  5. Take I-75 S toward Richmond/Knoxville (Crossing into Tennessee).

    Then 164.70 miles
  6. Stay straight to go onto I-275 S.

    Then 2.94 miles
  7. Merge onto Henley St/US-441 S/TN-71/TN-33 toward Downtown.

    Then 1.16 miles
  8. Turn left onto W Main St/US-70 E/US-11 N/TN-1/TN-71/TN-33. Continue to follow W Main St.

    1. W Main St is just past Cumberland Ave

    2. Church Street United Mthdst is on the corner

    3. If you are on US-441 S and reach E Blount Ave you've gone about 0.4 miles too far

    Then 0.28 miles
  9. Turn left onto S Gay St.

    1. S Gay St is just past Market St

    2. If you reach State St you've gone a little too far

    Then 0.06 miles
  10. Welcome to KNOXVILLE, TN.

    1. If you reach W Church Ave you've gone a little too far

    Then 0.00 miles