MapQuest Driving Directions Jackson, MO to Birmingham, AL

Jackson, MO

Birmingham, AL

Route 1

Go south on I-55 S (Crossing into Arkansas).
412.361 miles
6hr 31min
  1. Start out going east on E Main St toward Lacey St.

    Then 1.82 miles
  2. Merge onto I-55 S toward Sikeston (Crossing into Arkansas).

    1. If you are on Lasalle Ave and reach Veterans Memorial Dr you've gone about 0.3 miles too far

    Then 169.82 miles
  3. Keep right to take I-55 S toward Memphis/Jackson Miss (Crossing into Tennessee).

    Then 10.90 miles
  4. Take I-240 E toward Nashville.

    Then 4.04 miles
  5. Merge onto US-78 E via EXIT 21 toward Birmingham (Passing through Mississippi, then crossing into Alabama).

    Then 210.57 miles
  6. Take the US-78 exit, EXIT 85, toward Adamsville/Birmingham.

    Then 0.32 miles
  7. Merge onto US-78 E/AL-4 toward Adamsville/Birmingham/Graysville.

    Then 11.98 miles
  8. Merge onto I-20 E/I-59 N toward Downtown.

    Then 2.64 miles
  9. Take the 22nd St exit, EXIT 125B.

    Then 0.22 miles
  10. Turn slight right onto 22nd St N.

    Then 0.06 miles
  11. Welcome to BIRMINGHAM, AL.

    1. If you reach 7th Ct N you've gone a little too far

    Then 0.00 miles