MapQuest Driving Directions Tupelo, MS to Birmingham, AL

Tupelo, MS

Birmingham, AL

Route 1

Go east on US-78 E (Crossing into Alabama).
133.016 miles
2hr 10min
  1. Start out going east on E Main St/MS-178 toward S Front St.

    Then 1.16 miles
  2. Turn left onto N Veterans Blvd.

    1. N Veterans Blvd is 0.8 miles past E Franklin St

    2. If you reach Wayside St you've gone a little too far

    Then 1.88 miles
  3. Merge onto US-78 E (Crossing into Alabama).

    Then 114.77 miles
  4. Take the US-78 exit, EXIT 85, toward Adamsville/Birmingham.

    Then 0.32 miles
  5. Merge onto US-78 E/AL-4 toward Adamsville/Birmingham/Graysville.

    Then 11.98 miles
  6. Merge onto I-20 E/I-59 N toward Downtown.

    Then 2.64 miles
  7. Take the 22nd St exit, EXIT 125B.

    Then 0.22 miles
  8. Turn slight right onto 22nd St N.

    Then 0.06 miles
  9. Welcome to BIRMINGHAM, AL.

    1. If you reach 7th Ct N you've gone a little too far

    Then 0.00 miles