MapQuest Driving Directions Winston Salem, NC to Charleston, SC

Winston Salem, NC

Charleston, SC

Route 1

Go west on I-40 Bus W/US-421 N.
290.216 miles
4hr 23min
  1. Start out going north on N Main St toward E 3rd St.

    Then 0.11 miles
  2. Turn left onto W 3rd St.

    1. Subway is on the left

    2. If you reach E 4th St you've gone a little too far

    Then 0.05 miles
  3. Take the 1st left onto N Liberty St.

    1. If you reach Town Run Ln you've gone a little too far

    Then 0.22 miles
  4. Merge onto I-40 Bus W/US-421 N.

    Then 4.89 miles
  5. Merge onto I-40 W via EXIT 1 on the left toward I-40/Greensboro/Statesville.

    Then 35.96 miles
  6. Merge onto I-77 S via EXIT 152A toward Charlotte (Crossing into South Carolina).

    Then 123.65 miles
  7. Keep left to take I-77 S toward Charleston/I-20 E/Florence.

    Then 17.98 miles
  8. Merge onto I-26 E via the exit on the left toward Charleston.

    Then 105.41 miles
  9. Take the Meeting St exit, EXIT 221B, on the left toward Visitor Ctr.

    Then 0.39 miles
  10. Turn right onto US-52 E/Meeting St. Continue to follow Meeting St.

    1. If you are on US-52 W and reach Lee St you've gone a little too far

    Then 1.57 miles
  11. Welcome to CHARLESTON, SC.

    1. Your destination is just past Court House Sq

    2. If you reach Saint Michaels Aly you've gone a little too far

    Then 0.00 miles