MapQuest Driving Directions Cincinnati, OH to Charleston, SC

Cincinnati, OH

Charleston, SC

Route 1

Go west on W 9th St.
621.0961 miles
9hr 31min
  1. Start out going north on Vine St toward Garfield Pl.

    Then 0.07 miles
  2. Take the 2nd left onto W 9th St/US-22 W/OH-3. Continue to follow W 9th St.

    1. W 9th St is just past Garfield Pl

    2. Childrens Learning Ctr is on the corner

    3. If you reach Prior St you've gone a little too far

    Then 0.57 miles
  3. Merge onto I-75 S toward I-71 S/Louisville/Lexington (Crossing into Kentucky).

    Then 19.68 miles
  4. Keep left to take I-75 S toward Lexington (Crossing into Tennessee).

    Then 226.49 miles
  5. Stay straight to go onto I-275 S.

    Then 0.37 miles
  6. Merge onto I-640 E/US-25W S/TN-9 E via EXIT 3 toward Asheville.

    Then 6.98 miles
  7. Merge onto I-40 E via the exit on the left toward Asheville.

    Then 28.51 miles
  8. Keep right to take I-40 E toward Asheville (Crossing into North Carolina).

    Then 76.21 miles
  9. Merge onto I-26 E via EXIT 46A toward Hendersonville/Spartanburg (Crossing into South Carolina).

    Then 260.27 miles
  10. Take the Meeting St exit, EXIT 221B, on the left toward Visitor Ctr.

    Then 0.39 miles
  11. Turn right onto US-52 E/Meeting St. Continue to follow Meeting St.

    1. If you are on US-52 W and reach Lee St you've gone a little too far

    Then 1.57 miles
  12. Welcome to CHARLESTON, SC.

    1. Your destination is just past Court House Sq

    2. If you reach Saint Michaels Aly you've gone a little too far

    Then 0.00 miles