MapQuest Driving Directions Cincinnati, OH to Greenville, SC

Cincinnati, OH

Greenville, SC

Route 1

Go west on W 9th St.
416.31 miles
6hr 38min
  1. Start out going north on Vine St toward Garfield Pl.

    Then 0.07 miles
  2. Take the 2nd left onto W 9th St/US-22 W/OH-3. Continue to follow W 9th St.

    1. W 9th St is just past Garfield Pl

    2. Childrens Learning Ctr is on the corner

    3. If you reach Prior St you've gone a little too far

    Then 0.57 miles
  3. Merge onto I-75 S toward I-71 S/Louisville/Lexington (Crossing into Kentucky).

    Then 19.68 miles
  4. Keep left to take I-75 S toward Lexington (Crossing into Tennessee).

    Then 226.49 miles
  5. Stay straight to go onto I-275 S.

    Then 0.37 miles
  6. Merge onto I-640 E/US-25W S/TN-9 E via EXIT 3 toward Asheville.

    Then 6.98 miles
  7. Merge onto I-40 E via the exit on the left toward Asheville.

    Then 28.51 miles
  8. Keep right to take I-40 E toward Asheville (Crossing into North Carolina).

    Then 76.21 miles
  9. Merge onto I-26 E/US-74 E via EXIT 46A toward Hendersonville/Spartanburg.

    Then 22.82 miles
  10. Merge onto US-25 S via EXIT 54 toward US-176/NC-225/Greenville (Crossing into South Carolina).

    Then 27.00 miles
  11. Take US-25 Bus S toward Greenville.

    Then 6.89 miles
  12. Turn slight left onto Buncombe St/US-25 Bus S/SC-183. Continue to follow SC-183.

    1. SC-183 is 0.1 miles past Harvley St

    2. Buttercream Bakehouse LLC is on the corner

    Then 0.60 miles
  13. Turn right onto N Main St.

    1. N Main St is just past N Laurens St

    2. If you are on E North St and reach N Brown St you've gone a little too far

    Then 0.13 miles
  14. Welcome to GREENVILLE, SC.

    1. Your destination is just past Piazza Plz

    2. If you are on S Main St and reach W McBee Ave you've gone a little too far

    Then 0.00 miles