MapQuest Driving Directions Middletown, OH to Louisville, KY

Middletown, OH

Louisville, KY

Route 1

135.436 miles
2hr 10min
  1. Start out going east on Central Ave toward S Clinton St/OH-4/OH-73.

    Then 0.57 miles
  2. Turn right onto S University Blvd/OH-122. Continue to follow OH-122.

    1. OH-122 is just past Charles St

    2. If you reach Crawford St you've gone a little too far

    Then 4.56 miles
  3. Merge onto I-75 S toward Cincinnati (Crossing into Kentucky).

    Then 51.39 miles
  4. Merge onto I-71 S via EXIT 173 toward Louisville.

    Then 77.49 miles
  5. Merge onto I-65 S/Dr Martin Luther King Jr Expy S toward I-65 S/Louisville/Nashville.

    Then 0.86 miles
  6. Take the Jefferson St exit, EXIT 136-C, toward Downtown.

    Then 0.19 miles
  7. Keep left to take the Brook St ramp.

    Then 0.09 miles
  8. Merge onto S Brook St.

    Then 0.19 miles
  9. Turn left onto E Main St/US-60 W/US-31E N.

    1. E Main St is just past E Market St

    2. If you are on N Brook St and reach E Washington St you've gone a little too far

    Then 0.09 miles
  10. Welcome to LOUISVILLE, KY.

    1. If you are on W Main St and reach S 2nd St you've gone a little too far

    Then 0.00 miles