MapQuest Driving Directions Greenville, SC to Charleston, SC

Greenville, SC

Charleston, SC

Route 1

Go east on E North St/SC-183.
213.141 miles
3hr 13min
  1. Start out going north on N Main St toward E Coffee St.

    Then 0.13 miles
  2. Take the 2nd right onto E North St/SC-183.

    1. E North St is just past E Coffee St

    2. If you reach College St you've gone about 0.1 miles too far

    Then 0.71 miles
  3. Stay straight to go onto I-385 S.

    Then 42.00 miles
  4. I-385 S becomes I-26 E.

    Then 168.35 miles
  5. Take the Meeting St exit, EXIT 221B, on the left toward Visitor Ctr.

    Then 0.39 miles
  6. Turn right onto US-52 E/Meeting St. Continue to follow Meeting St.

    1. If you are on US-52 W and reach Lee St you've gone a little too far

    Then 1.57 miles
  7. Welcome to CHARLESTON, SC.

    1. Your destination is just past Court House Sq

    2. If you reach Saint Michaels Aly you've gone a little too far

    Then 0.00 miles