MapQuest Driving Directions Greer, SC to Louisville, KY

Greer, SC

Louisville, KY

Route 1

Go northwest on SC-290.
410.154 miles
6hr 32min
  1. Start out going west on W Poinsett St/SC-290/SC-101 toward Davenport Ave.

    Then 1.51 miles
  2. Turn left onto W Wade Hampton Blvd/US-29 S/SC-290/SC-101.

    1. Rite Aid is on the corner

    2. If you are on Mount Vernon Rd and reach Chestnut Ave you've gone a little too far

    Then 0.10 miles
  3. Take the 1st right onto O'Neal Rd/SC-101.

    1. If you reach N Buncombe Rd you've gone about 0.1 miles too far

    Then 0.35 miles
  4. Turn slight right onto O'Neal Rd/SC-290/SC-101. Continue to follow SC-290.

    1. SC-290 is just past Blue Ridge Dr

    Then 11.52 miles
  5. Take US-25 N (Crossing into North Carolina).

    1. US-25 N is 0.2 miles past N Speer Rd

    Then 20.25 miles
  6. Merge onto I-26 W/US-74 W via the exit on the left toward Hendersonville/Asheville.

    Then 22.89 miles
  7. Merge onto I-40 W via EXIT 31B on the left toward Canton/Knoxville (Crossing into Tennessee).

    Then 104.91 miles
  8. Merge onto I-640 W/US-25W N/TN-9 W via EXIT 393 toward I-75 N/Lexington.

    Then 6.89 miles
  9. Merge onto I-75 N via EXIT 3A toward Lexington (Crossing into Kentucky).

    Then 171.53 miles
  10. Keep left to take I-64 W via EXIT 118 toward Frankfort/Louisville.

    Then 68.07 miles
  11. Merge onto Mellwood Ave/US-60 E/US-42 E via EXIT 7.

    Then 0.29 miles
  12. Turn left onto Frankfort Ave/US-60 W.

    1. Frankfort Ave is just past Stevenson Ave

    2. If you reach Brownsboro Rd you've gone about 0.2 miles too far

    Then 0.13 miles
  13. Take the 1st left onto Story Ave/US-60 W/US-42 W. Continue to follow US-60 W.

    1. US-60 W is just past Blue Horse Ave

    2. Sergio's World Beers is on the corner

    3. If you reach Stoecker Ave you've gone a little too far

    Then 1.73 miles
  14. Welcome to LOUISVILLE, KY.

    1. Your destination is just past S Brook St

    2. If you are on W Main St and reach S 2nd St you've gone a little too far

    Then 0.00 miles