MapQuest Driving Directions Knoxville, TN to Indianapolis, IN

Knoxville, TN

Indianapolis, IN

Route 1

357.411 miles
5hr 29min
  1. Start out going southwest on Cumberland Ave toward Market St.

    Then 0.27 miles
  2. Turn right onto Henley St/US-70 E/US-11 N/US-441 N/TN-1/TN-71/TN-33.

    1. Henley St is just past Locust St

    2. If you are on Cumberland Ave and reach W Main St you've gone about 0.1 miles too far

    Then 0.18 miles
  3. Merge onto I-275 N toward Lexington.

    Then 3.95 miles
  4. I-275 N becomes I-75 N (Crossing into Kentucky).

    Then 170.89 miles
  5. Keep left to take I-64 W via EXIT 118 toward Frankfort/Louisville.

    Then 68.83 miles
  6. Merge onto I-71 S via EXIT 5A on the left toward I-65/Nashville/Indianapolis.

    Then 0.49 miles
  7. Merge onto I-65 N via the exit on the left toward Indianapolis (Crossing into Indiana).

    Then 111.77 miles
  8. Take the Washington St exit, EXIT 111.

    Then 0.20 miles
  9. Stay straight to go onto N Pine St.

    Then 0.09 miles
  10. Take the 2nd left onto E Market St.

    1. E Market St is just past E Washington St

    2. If you are on E Ohio St and reach Herman St you've gone about 0.1 miles too far

    Then 0.74 miles
  11. Welcome to INDIANAPOLIS, IN.

    1. Your destination is just past N Talbott St

    2. If you reach Monument Cir you've gone a little too far

    Then 0.00 miles