MapQuest Driving Directions Knoxville, TN to Roanoke, VA

Knoxville, TN

Roanoke, VA

Route 1

259.412 miles
3hr 58min
  1. Start out going southeast on S Gay St toward W Main St.

    Then 0.06 miles
  2. Take the 1st left onto W Main St.

    1. If you reach W Hill Ave you've gone a little too far

    Then 0.06 miles
  3. Merge onto TN-158.

    Then 0.80 miles
  4. Merge onto I-40 E toward Asheville.

    Then 32.87 miles
  5. Merge onto I-81 N via EXIT 421 on the left toward Bristol (Crossing into Virginia).

    Then 219.02 miles
  6. Merge onto I-581 S/US-220 S via EXIT 143 toward Airport/Roanoke.

    Then 5.86 miles
  7. Take the US-11 S/US-220 Bus S exit, EXIT 5, toward Downtown.

    Then 0.12 miles
  8. Merge onto Williamson Rd NE/US-221 S via the ramp on the left toward Downtown.

    Then 0.37 miles
  9. Turn right onto Campbell Ave SE.

    1. Campbell Ave SE is just past Salem Ave SE

    2. Benny Marconi's is on the right

    3. If you reach Kirk Ave SE you've gone a little too far

    Then 0.16 miles
  10. Take the 3rd left onto S Jefferson St.

    1. S Jefferson St is just past Wall St SE

    2. City Corner Fresh Foods is on the corner

    3. If you are on Campbell Ave SW and reach 1st St SW you've gone about 0.1 miles too far

    Then 0.09 miles
  11. Welcome to ROANOKE, VA.

    1. Your destination is just past Kirk Ave SE

    2. If you reach Luck Ave SW you've gone a little too far

    Then 0.00 miles