MapQuest Driving Directions Roanoke, VA to Lexington, KY

Roanoke, VA

Lexington, KY

Route 1

Go north on I-581 N/US-220 N.
354.381 miles
5hr 47min
  1. Start out going north on S Jefferson St toward Kirk Ave SE.

    Then 0.09 miles
  2. Take the 2nd right onto Campbell Ave SE/US-11 N.

    1. Campbell Ave SE is just past Kirk Ave SE

    2. City Corner Fresh Foods is on the corner

    3. If you reach Salem Ave SE you've gone a little too far

    Then 0.17 miles
  3. Turn left onto Williamson Rd SE/US-11 N/US-221 N.

    1. Williamson Rd SE is just past Market Sq SE

    2. Alejandro's Mexican Grill is on the right

    3. If you reach 3rd St SE you've gone a little too far

    Then 0.35 miles
  4. Merge onto I-581 N/US-220 N toward Lexington/Salem.

    Then 5.70 miles
  5. Merge onto I-81 S via EXIT 1S on the left toward Salem/Bristol.

    Then 25.06 miles
  6. Take the US-11/US-460 E/US-460 Bus exit, EXIT 118C, toward Christiansburg/Shawsville.

    Then 0.76 miles
  7. Merge onto Roanoke St/US-11 S/US-460 W toward Christiansburg/Virginia Tech.

    Then 0.90 miles
  8. Merge onto US-460 W toward Blacksburg (Crossing into West Virginia).

    Then 55.17 miles
  9. Merge onto I-77 N toward Beckley/TOLL ROAD (Portions toll).

    1. If you are on US Highway 460 and reach Service Rd you've gone about 0.3 miles too far

    Then 91.68 miles
  10. Keep left to take I-64 W via EXIT 101 toward Huntington (Crossing into Kentucky).

    Then 168.45 miles
  11. Merge onto I-75 S via EXIT 81 on the left toward Richmond/Knoxville.

    Then 1.46 miles
  12. Take the US-60 exit, EXIT 110, toward Lexington.

    Then 0.24 miles
  13. Keep right to take the ramp toward Lexington.

    Then 0.03 miles
  14. Merge onto US-60 W.

    Then 3.83 miles
  15. Turn right onto E Main St/US-60 W/US-25 N/US-421 N.

    Then 0.50 miles
  16. Welcome to LEXINGTON, KY.

    1. Your destination is 0.1 miles past S Martin Luther King Blvd

    2. If you are on W Main St and reach Wrehn Ct you've gone a little too far

    Then 0.00 miles