MapQuest Driving Directions Roanoke, VA to Knoxville, TN

Roanoke, VA

Knoxville, TN

Route 1

Go north on I-581 N/US-220 N.
259.703 miles
4hr 0min
  1. Start out going north on S Jefferson St toward Kirk Ave SE.

    Then 0.09 miles
  2. Take the 2nd right onto Campbell Ave SE/US-11 N.

    1. Campbell Ave SE is just past Kirk Ave SE

    2. City Corner Fresh Foods is on the corner

    3. If you reach Salem Ave SE you've gone a little too far

    Then 0.17 miles
  3. Turn left onto Williamson Rd SE/US-11 N/US-221 N.

    1. Williamson Rd SE is just past Market Sq SE

    2. Alejandro's Mexican Grill is on the right

    3. If you reach 3rd St SE you've gone a little too far

    Then 0.35 miles
  4. Merge onto I-581 N/US-220 N toward Lexington/Salem.

    Then 5.70 miles
  5. Merge onto I-81 S via EXIT 1S on the left toward Salem/Bristol.

    Then 70.90 miles
  6. Keep left to take I-81 S toward Bristol (Crossing into Tennessee).

    Then 148.29 miles
  7. Merge onto I-40 W via EXIT 1B toward Knoxville.

    Then 32.15 miles
  8. Merge onto TN-158 W via EXIT 388A toward US-441 S/Downtown/Univ of Tenn.

    Then 1.79 miles
  9. Take the Cumberland Ave/State St ramp toward Knoxville.

    Then 0.20 miles
  10. Keep left at the fork in the ramp.

    Then 0.02 miles
  11. Stay straight to go onto Cumberland Ave.

    Then 0.06 miles
  12. Welcome to KNOXVILLE, TN.

    1. If you reach Market St you've gone a little too far

    Then 0.00 miles