Palermo is a census-designated place (CDP) in Butte County, California, United States. The population was 5,382 at the 2010 census, down from 5,720 at the 2000 census.
According to the United States Census Bureau, the CDP has a total area of 29.2 square miles (75.6 km²), of which, 99.95% of it is land and 0.05% is water.
The town was named after Palermo, Sicily due to its excellent climate for growing olives. The first post office was established in 1888.