Camanche is a city in Clinton County, Iowa, United States on the Mississippi River. The population was 4,215 at the 2000 census.
Camanche was founded by a man with the name of Dr. George Peck in the late 1830s, who happens to be buried in the Rosehill Cemetery in Camanche. On June 3, 1860, Camanche was struck by an intense tornado. With a damage path 1,000 yards (910 m) wide and 80 miles (130 km) long, this tornado killed 92 people and injured 200. The death toll in Camanche alone was 22 dead and that is according to "Harpers Weekly" dated June 23, 1860, and also the granite boulder tombstone under which they are buried in the cemetery in Camanche. But estimates vary widely some ranging from 300 people killed to less than 50 killed in the tornado.
Camanche is located at 41°47′11″N 90°15′36″W / 41.786470°N 90.259898°W / 41.786470; -90.259898 (41.786470, -90.259898).