Cherokee is a city in Cherokee County, Iowa, United States. The population was 5,932 at the 2010 Census, up from 5,369 at the 2000 census. It is the county seat of Cherokee County. Cherokee is also the home of the Cherokee Mental Health Institute, under the Iowa Department of Human Services. The nearby Cherokee Sewer Site is a well-preserved prehistoric Indian bison-processing site, which helped to redefine the Archaic period in the Midwest, and the Phipps Site is a National Historic Landmark 1000-year-old Plains farming village that may have been fortified.
Cherokee is located at 42°45′03″N 95°33′02″W / 42.750818°N 95.550472°W / 42.750818; -95.550472. It is situated near the Little Sioux River.
According to the United States Census Bureau, the city has a total area of 6.4 square miles (16.7 km²), of which, 6.4 square miles (16.6 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.31%) is water.