Keokuk ( /kiːəkʌk/) is a city in the southeastern part of the U.S. state of Iowa and one of the county seats of Lee County. The other county seat is Fort Madison. The population was 11,427 at the 2000 census. The city is named after the Sauk Chief Keokuk, who is thought to be buried in Rand Park. It is located in the extreme southeast corner of Iowa where the Des Moines River meets with the Mississippi. It is located at the junction of U.S. Routes 61, 136 and 218. Just across the rivers are the towns of Hamilton and Warsaw, Illinois, and Alexandria, Missouri.
Keokuk, along with the city of Fort Madison, is a principal city of the Fort Madison–Keokuk Micropolitan Statistical Area, which includes all of Lee County, Iowa and Clark County, Missouri.
Situated between the Des Moines and Mississippi rivers, the area that became Keokuk had access to a large trading area and was an ideal location for settlers. In 1820, the US Army prohibited soldiers stationed along the Mississippi River from having wives who were Native American. Dr. Samuel C. Muir, a surgeon stationed at Fort Edwards (near present-day Warsaw, Illinois), instead resigned his commission rather than leave his Indian wife and crossed the river to resettle. He built a log cabin for them at the bottom of the bluff, and became the area’s first white settler.