Knoxville is a city in Knox County, Illinois, United States. The population was 3,183 at the 2000 census. It is part of the Galesburg Micropolitan Statistical Area.
Knoxville is located just southeast of the City of Galesburg. There is a public square in the center of town with several historic buildings surrounding it including Knox County's first courthouse, city hall, the Sanburn log cabin, and several other important buildings. The Knox County Fairgrounds is just north of Knoxville on Henderson Street. Knoxville is served with two exits on Interstate 74, at U.S. Highway 150 east of town and at Henderson Streen north of town. U.S. Highway 150 runs east and west through Knoxville and serves as the main business throughfare. Illinois Highway 97 and Knox County Highway 8 also enter the city. The Knoxville Cemetery lies in the northern part of town on Market Street. The Knox County Nursing Home is located in the city. There is a grade school in Knoxville, as well as Knoxville High School. Among the attractions in Knoxville are the historic buildings, Walnut Grove Farm, the Knox County Fair held in August, and the annual Knox County Scenic Drive held in October.
Knoxville was established on January 15, 1831, and called Henderson until its name was changed to Knoxville on December 22, 1832 when it became the county seat. It was one of the first 10 municipalities incorporated in the state and is the oldest town in Knox County.