Pierron is a village in Bond and Madison counties, Illinois, United States. The population was 653 at the 2000 census.
Pierron was incorporated as a village in 1893. It is on the Bond and Madison county line. Its post office was established in 1870.
Pierron is located at 38°46′44″N 89°33′34″W / 38.77889°N 89.55944°W / 38.77889; -89.55944 (38.778767, -89.559306).