Applegate is a village in Sanilac County of the U.S. state of Michigan. As of the 2000 census, the village population was 287. Applegate is in the southeast corner of Washington Township on the boundary with Sanilac Township.
Applegate originated in 1856 when George Pack (brother of John Pack) built a sawmill here.
According to the United States Census Bureau, the village has a total area of 1.0 square miles (2.6 km²), all land.