Caro is a city in and the county seat of Tuscola County, Michigan, United States. The population was 4,229 at the 2010 census and 4,145 at the 2000 census (an increase of about 2%).
Caro is located northeast of Flint and east of Saginaw in Michigan's Thumb region. It is the largest community in the Thumb, both by population and by area and is an industrial and commercial center for the region as well.
The first white settler in what is now the city of Caro was Samuel P. Sherman, who purchased 63 acres (250,000 m2) in the north half of the northwest quarter of section 3 in Indianfields Township on September 8, 1852. Prior to this, only two land sales had been recorded, both for lumbering or speculative purposes. His son, William E. Sherman, had worked in the lumber industry nearby on the Cass River for some time prior to 1852 and William's favorable report persuaded his father to visit in 1851 and afterwards purchased several tracts of land in addition to his initial purchase.