Caruthersville is the most populous city and county seat of Pemiscot County, located along the Mississippi River in the bootheel of southeastern Missouri in the United States. The population was 6,760 at the 2000 census.
Caruthersville lies deep in Missouri's bootheel on the Mississippi River. The word "Pemiscot" comes from an Indian word meaning "liquid mud". This is not inappropriate, since Mississippi waters have frequently flooded the flatlands. While those waters have brought disaster to Caruthersville homes, they have also attracted people to the region because of the fertile alluvial land they have helped to create.
Native Americans inhabited the land around Caruthersville before European settlement, they were part of the civilization that built huge earth mounds throughout the Mississippi Valley. One such land mass remains, rising 270 feet above sea level about four miles southwest of Caruthersville. It stands in sharp contrast to the surrounding delta-like plain.