Centerville is a city in Reynolds County, Missouri, along the West Fork of the Black River. The population was 171 at the 2000 census. It is the county seat of Reynolds County.
The West Fork Mine is a lead-zinc-silver-copper mine located near Centerville. Owned by ASARCO, it reached full production of 3,400 tons/day of ore in August 1988. The mine produces about 46,000 tons of lead, 6,800 tons zinc, and 3,900 kg of silver per year.
According to the United States Census Bureau, Centerville has a total area of 0.3 square miles (0.8 km²), all of it land.