Drew is a city in Sunflower County, Mississippi, United States. The population was 2,434 at the 2000 census. Drew, a rural community, is in the vicinity of several plantations and the Mississippi State Penitentiary, a Mississippi Department of Corrections prison for men.
Drew is located at 33°48′36″N 90°31′50″W / 33.81°N 90.53056°W / 33.81; -90.53056 (33.809923, -90.530530). According to the United States Census Bureau, the city has a total area of 1.1 square miles (2.9 km²), all of it land.
Drew is located on U.S. Route 49 West, on the route between Jackson and Clarksdale. Drew is 8 miles (13 km) south of the Mississippi State Penitentiary (Parchman).