Picayune is the largest city in Pearl River County, Mississippi, United States. The population was 10,878 at the 2010 census. Located approximately 45 miles (72 km) from New Orleans, Hattiesburg, and Gulfport/Biloxi. The Stennis Space Center is 10 miles (16 km) away.
According to the United States Census Bureau, the city has a total area of 11.8 square miles (30.6 km²), of which, 11.8 square miles (30.5 km²) of it is land and 0.04 square miles (0.1 km²) of it (7.34%) is water.
As of the census of 2000, there were 10,535 people, 4,100 households, and 2,865 families residing in the city. The population density was 895.6 people per square mile (345.9/km²). There were 4,568 housing units at an average density of 388.3 per square mile (150.0/km²). The racial makeup of the city was 62.02% White, 35.92% African American, 0.38% Native American, 0.30% Asian, 0.05% Pacific Islander, 0.18% from other races, and 1.15% from two or more races. Hispanic or Latino of any race were 1.15% of the population.