Rienzi is a town in Alcorn County, Mississippi, United States. The population was 330 at the 2000 census.
Rienzi was named for Cola di Rienzo, a medieval Italian politician.[why?] The original town was settled in 1830 and was located one mile west of its current location, near the Nesly Williams Plantation.
On April 27, 2011, a tornado hit Rienzi as part of the April 25–28, 2011 tornado outbreak, causing minor home damages and downing trees. The tornado was classified as an EF-0, with estimated wind speeds of 65 miles per hour (105 km/h). The tornado's path of destruction was 50 yards (46 m) wide and the tornado traveled a path of 2.32 miles (3.73 km).