Vancleave is a census-designated place (CDP) in Jackson County, Mississippi, United States. It is part of the Pascagoula, Mississippi Metropolitan Statistical Area. The population was 4,910 at the 2000 census.
Vancleave is located at 30°32′49″N 88°40′21″W / 30.54694°N 88.6725°W / 30.54694; -88.6725 (30.546911, -88.672612).
According to the United States Census Bureau, the CDP has a total area of 44.1 square miles (114.2 km²), of which, 43.4 square miles (112.4 km²) of it is land and 0.7 square miles (1.8 km²) of it (1.61%) is water.