Genoa is a city in Nance County, Nebraska, United States. The population was 981 at the 2000 census. Genoa is a community rich in culture and farming is a major source of income for much of the surrounding area. The city was founded by the Mormons in 1857. In the fall of 1859, the Mormon Colony was forced to abandon Genoa when the town and surrounding area were incorporated into the newly created Pawnee Indian Reservation. The Pawnee Indian Agency utilized the structures vacated by the Mormons.
Genoa is located at 41°26′51″N 97°43′57″W / 41.4475°N 97.7325°W / 41.4475; -97.7325 (41.447638, -97.732455).
According to the United States Census Bureau, the city has a total area of 0.8 square miles (2.1 km²), of which, 0.8 square miles (2.0 km²) of it is land and 1.25% is water.