Tuskahoma is a community in northern Pushmataha County, Oklahoma, four miles east of Clayton, Oklahoma.
A United States Post Office was established at Tushka Homma, Indian Territory on February 27, 1884. On October 28, 1891, the spelling changed to Tushkahomma. On December 6, 1910 the official spelling changed to its present rendering, Tuskahoma. The community has also been served by post office locations at nearby Council House, Oklahoma (1872–1880) and Lyceum, Oklahoma (1896–1900). Council House was located at the Choctaw Capitol Building and Lyceum was located at the former Choctaw Female Academy.
Tuskahoma is a compound word meaning “red warrior” in the Choctaw language.