Greenville is a borough in Mercer County, Pennsylvania. Located along the Shenango River, Greenville is roughly 80 miles from both Pittsburgh and Cleveland. Greenville is part of the Youngstown–Warren–Boardman, OH-PA Metropolitan Statistical Area, which is home to 570,000 people. Thiel College is located in Greenville.
Greenville is located in northwest Pennsylvania at 41°24′18″N 80°23′12″W / 41.405°N 80.38667°W / 41.405; -80.38667 (41.404998, −80.386651), along the Shenango River. Its altitude is 945 feet (288 m) above sea level.
Greenville was known for its manufacturing interests, including railroad shops, bridge works, gristmills, a cement-block plant, an automobile factory, foundries and machine shops, saw and planing mills, steelworks, a railroad-car manufacturer, and flour mills. Water power was supplied by the Shenango River.