Grindstone-Rowes Run is a census-designated place (CDP) in Fayette County, Pennsylvania, United States. The population was 1,141 at the 2000 census. The village is Grindstone is located in Jefferson Township, while Rowes Run is located in Redstone Township.
Grindstone-Rowes Run is located at 40°0′44″N 79°49′15″W / 40.01222°N 79.82083°W / 40.01222; -79.82083 (40.012106, -79.820708).
According to the United States Census Bureau, the CDP has a total area of 2.2 square miles (5.6 km²), all of it land.