About This Place
Carlisle is a town in Union County, South Carolina, United States. The population was 436 according to the 2010 United States Census.
Carlisle is located at 34°35′30″N 81°27′52″W / 34.59167°N 81.46444°W / 34.59167; -81.46444 (34.591674, -81.464518).
According to the United States Census Bureau, the town has a total area of 1.4 square miles (3.7 km²), all of it land.