Clio is a town in Marlboro County, South Carolina, United States. The population was 774 at the 2000 census.
Clio is located at 34°34′48″N 79°32′36″W / 34.58°N 79.54333°W / 34.58; -79.54333 (34.579921, -79.543401).
According to the United States Census Bureau, the town has a total area of 0.8 square miles (2.2 km²), all of it land. Previous Mayor Leroy Woods, Current mayor Hamer McRae