Pickstown is a town in Charles Mix County, South Dakota, United States. The population was 201 at the 2010 census. It was named after Lewis A. Pick, director of the Missouri River office of the United States Army Corps of Engineers.
Pickstown is located at 43°3′59″N 98°31′55″W / 43.06639°N 98.53194°W / 43.06639; -98.53194 (43.066418, -98.531991).
According to the United States Census Bureau, the town has a total area of 0.6 square miles (1.7 km²), all of it land.