Ladysmith is a city in Rusk County, Wisconsin, United States. The population was 3,932 at the 2000 census. It is the county seat of Rusk County. It is the former location of Mount Senario College, which closed in 2002 due to significant debt. For the 2006-2007 school year, part of the former campus was operated as Concordia Preparatory School, a private Christian high school. That institution also faced financial problems and closed. Silver Lake College of Manitowoc, Wisconsin began offering courses at Mount Senario, renamed "Mount Senario Education Center", beginning September, 2009. A tornado hit Ladysmith on Labor Day in 2002.
Ladysmith is located at 45°27′50″N 91°6′0″W / 45.46389°N 91.1°W / 45.46389; -91.1. According to the United States Census Bureau, the city has a total area of 4.3 square miles (11.1 km²), of which, 3.9 square miles (10.1 km²) of it is land and 0.4 square miles (1.0 km²) of it (8.67%) is water.
As of the census of 2000, there were 3,932 people, 1,570 households, and 916 families residing in the city. The population density was 1,008.9 people per square mile (389.3/km²). There were 1,660 housing units at an average density of 425.9 per square mile (164.3/km²). The racial makeup of the city was 96.31% White, 1.48% African American, 0.56% Native American, 0.48% Asian, 0.13% Pacific Islander, 0.10% from other races, and 0.94% from two or more races. Hispanic or Latino of any race were 0.76% of the population.