Thayne is a town in Lincoln County, Wyoming, United States. The population was 341 at the 2000 census.
Randall Luthi, a former Speaker of the Wyoming House of Representatives, practices law in Thayne and is managing partner of a nearby ranch.
Thayne is located at 42°55′11″N 111°0′3″W / 42.91972°N 111.00083°W / 42.91972; -111.00083 (42.919754, -111.000714), at 5945 feet in elevation. It sits in the northern portion of Star Valley, close to the Salt River. It is surrounded by green grassland and ranches, with forested mountains at the valley's edge.