The Biggest Zoo in the U.S. Hosts Actual Safari Adventures

By: Wren Corvayne  | 
Lunchtime! Jene Smu / Shutterstock

Ever wondered about the biggest zoo in the U.S.? Well, buckle up, because it's about way more than just acreage and animal numbers.

These zoos are extraordinary wildlife wonderlands, bursting with amazing wildlife conservation, cutting-edge animal care and awe-inspiring habitats that transport you from African savannas straight to icy Arctic tundras.

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Grab your safari hat and camera, fellow animal lovers ... here’s your ultimate, can't-miss guide to the largest zoos in the United States.

1. North Carolina Zoo (Asheboro, NC)

Get ready to explore, because the North Carolina Zoo is enormous. Spanning a jaw-dropping 500 acres (202 hectares), it's the largest walk-through zoo on the planet!

Picture African elephants majestically wandering, mountain lions on the prowl, and expansive natural habitats bustling with incredible local wildlife like grizzly bears and rare red wolves.

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Their wildlife conservation game is strong, protecting endangered species such as critically endangered vultures and unique native plants.

2. San Diego Zoo Safari Park (Escondido, CA)

You know the world-famous zoo in San Diego, but its sister, the Safari Park, is an even bigger deal, covering 1,800 acres (728 hectares).

Experience a real-life safari adventure, from feeding gentle giraffes to watching powerful African lions lounging in natural settings. Their global conservation programs are just as impressive, making it one of the absolute best zoos for wild animal sightings.

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3. Omaha's Henry Doorly Zoo and Aquarium (Omaha, NE)

Prepare to be amazed at Omaha's Henry Doorly Zoo—162 acres (66 hectares) of pure innovation!

Home to the world's largest indoor desert, the spectacular Desert Dome, lush jungles and thrilling underground cave systems, this zoo excels in wildlife conservation through groundbreaking research at its Conservation Biology Institute, benefiting majestic creatures from snow leopards to western lowland gorillas.

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4. Bronx Zoo (Bronx, NY)

Think New York City lacks wildlife space? Think again! The iconic Bronx Zoo offers 265 acres (107 hectares) of adventure in the city's heart.

Make sure to visit the incredible Congo Gorilla Forest for up-close moments with playful western lowland gorillas. As one of America's oldest zoos, it passionately supports global conservation efforts protecting endangered animals like golden lion tamarins and Amur tigers.

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5. Columbus Zoo and Aquarium (Powell, OH)

With wildlife legend Jack Hanna’s touch, the sprawling 580-acre (235 hectares) Columbus Zoo and Aquarium spans 580 acres (235 hectares), including a 22-acre waterpark and an 18-hole golf course.

Explore immersive habitats showcasing exotic species and visit the beloved world-famous hippo Fiona, thanks to their sister partnership with the Cincinnati Zoo.

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Their conservation mission is robust, protecting endangered animals like manatees and Mexican wolves.

6. Zoo Miami (Miami, FL)

Florida’s largest zoo, Zoo Miami, covers an impressive 750 acres (304 hectares), offering mesmerizing, cageless habitats for a fully immersive wildlife experience.

Picture African leopards relaxing, river otters splashing and tropical botanical gardens flourishing. Their global conservation initiatives add even more excitement for wildlife enthusiasts.

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7. Minnesota Zoological Garden (Apple Valley, MN)

Sometimes just referred to as the Minnesota Zoo, this facility beautifully blends zoo animals, landscapes and education across its expansive 485 acres (196 hectares). Wander trails like the Living Northwest Trail to discover both native and exotic species.

Their exceptional breeding programs for endangered animals like snow leopards highlight their strong dedication to wildlife conservation.

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8. Smithsonian's National Zoological Park (Washington, D.C.)

In the heart of the nation’s capital, Smithsonian's National Zoo spans 163 acres (66 hectares), with an additional 3,200-acre Conservation Biology Institute in Front Royal, Virginia.

Famous for its adorable giant pandas and impactful global conservation programs, their Smithsonian Conservation Biology Institute champions biodiversity and animal care. Keep an eye out for playful golden lion tamarins!

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9. Cheyenne Mountain Zoo (Colorado Springs, CO)

High up on a mountain slope over 6,700 feet (2,042 meters) elevation, Cheyenne Mountain Zoo offers breathtaking views and thrilling wildlife encounters.

At 146 acres (59 hectares), it may be smaller, but it's huge in heart with fantastic giraffe feeding experiences, outstanding animal welfare and dazzling zoo lights events!

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10. Saint Louis Zoo (St. Louis, MO)

This premier free zoo packs 90 beautiful acres (36 hectares) with exotic species, enchanting walking trails and award-winning exhibits.

From mighty grizzly bears to critically endangered amphibians, Saint Louis Zoo passionately connects visitors to wildlife, prioritizes education, and fiercely supports biodiversity conservation.

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