Kasigluk ( /kəsɪɡlʊk/) (Kassigluq in Central Alaskan Yup'ik) is a census-designated place (CDP) in the Bethel Census Area in the U.S. state of Alaska. At the 2000 census the population was 543. Kasigluk consists of two smaller villages, called Akiuk and Akula.
Kasigluk is located at 60°53′31″N 162°32′9″W / 60.89194°N 162.53583°W / 60.89194; -162.53583 (60.892005, -162.535805).
According to the United States Census Bureau, the CDP has a total area of 13.2 square miles (34.3 km²), of which, 12.2 square miles (31.6 km²) of it is land and 1.1 square miles (2.7 km²) of it (8.00%) is water.