Greenbrier is a city in Faulkner County, Arkansas, United States. It is part of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area. The population was 3,042 at the 2000 census.
Prior to European settlement, Native American tribes, including the Quapaw and later the Cherokee Indians, lived in the area. Several historical figures of the Wild West such as Jim Bowie and Jesse James passed through the Greenbrier region toward Oklahoma and Texas. Settlers such as the Wiley brothers settled near East Fork Cadron around 1818, which is about eight miles east of Greenbrier today. In 1837, Jonathan Hardin settled near the Wiley settlement. Also in the early 19th century, the Casharagos settled north of Greenbrier in the present community of Republican.
Greenbrier is a town that developed from a minor brothel on the Butterfield Stagecoach route into a bustling city. The town was named for the painfully prickly greenbriar vines which grew along the creek through the town; removing these dense and thorny thickets was apparently a memorable experience for the founders. Greenbrier is located 12 miles north of Conway on Highway 65. Recent years have seen continued growth as Greenbrier becomes a bedroom community for nearby Conway.