Marmaduke is a city in Greene County, Arkansas, United States. The population was 1,158 at the 2000 census.
The town of Marmaduke was named for Confederate Major General John Sappington Marmaduke, who later served as Governor of Missouri. Marmaduke was said to have established a camp for his soldiers near the site of the present town. The Texas and St. Louis Railroad built through the area in 1882.
Marmaduke was incorporated on August 2, 1909, and had expanded to a fair-sized town by 1914 with two drugstores, three banks, three restaurants, a Methodist and Baptist church, two barber shops, a hotel, a boarding house, and two "dime stores". The primary employers at the time were a sawmill, a lumber mill, a stave mill, and large and cut timber distributors.