Holbrook (Navajo: Tiisyaakin) is a city in Navajo County, Arizona, United States. According to 2006 Census Bureau estimates, the population of the city was 5,126. The city is the county seat of Navajo County.
Holbrook was founded in 1881 or 1882, when the railroad was built, and named to honor the first chief engineer of the Atlantic and Pacific Railroad.
Holbrook is located at 34°54′26″N 110°9′46″W / 34.90722°N 110.16278°W / 34.90722; -110.16278 (34.907203, -110.162882).