Patagonia is a town in Santa Cruz County, Arizona, United States. As of 2010 Patagonia had a population of 913. Patagonia was formerly a supply center for nearby mines and ranches. Currently, it is a tourist destination, retirement community and arts & crafts center. The Nature Conservancy's Patagonia-Sonoita Creek Preserve is adjacent to the town.. Native Seeds/SEARCH also maintains an active farm for growing out and preserving seed of endangered crops in the area. They offer tours on a occasional basis.
Patagonia is located at 31°32′30″N 110°45′12″W / 31.54167°N 110.75333°W / 31.54167; -110.75333 (31.541743, -110.753428).
According to the United States Census Bureau, the town has a total area of 1.2 square miles (3.1 km²), all of it land.