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About InterAction E-mail Print InterAction is the largest alliance of U.S.-based international nongovernmental organizations ( NGOs ) focused on the world's poor and most vulnerable people. Samuel A. Worthington is InterAction's President and CEO. His long-standing commitment to the interconnected missions of international development and humanitarian action began long before his appointment to head InterAction. Prior to InterAction, Samuel Worthington was the CEO of Plan USA ; served on the Board of Directors of InterAction as Vice Chair, PVO Standards and Membership Committee Chair, and co-chaired its Commission on the Advancement of Women